Unifying Ideas for Non-Parametric Linkage Analysis
نویسندگان
چکیده
منابع مشابه
Unifying ideas for non-parametric linkage analysis.
OBJECTIVES Non-parametric linkage analysis (NPL) exploits marker allele sharing among affected relatives to map genes influencing complex traits. Computational barriers force approximate analysis on large pedigrees and the adoption of a questionable perfect data assumption (PDA) in assigning p values. To improve NPL significance testing on large pedigrees, we examine the adverse consequences of...
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ژورنال
عنوان ژورنال: Human Heredity
سال: 2011
ISSN: 1423-0062,0001-5652
DOI: 10.1159/000323752